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Smart Healing

Bioactive Glass

Introducing a new era of healthcare

Bonalive is a unique bone regeneration technology, enabling patients’ own biological processes to restore body function, through Smart Healing.

Unique bone regeneration technology

Naturally inhibits bacterial growth & stimulates bone formation

Antimicrobial resistance (AMR) is one of the greatest challenges facing healthcare today. In the face of growing resistance, we need solutions to an increasingly complex global problem. Solutions that are smarter and more sustainable for patients worldwide.

Coming to life at the intersection of biology and technology, Bonalive has introduced the concept of Smart Healing, which represents a new standard. A new era for patient care.

As Smart Healing enables increasingly antibiotic free patient care, our partnership with Bonalive provides Australians with biomaterial technologies that restore body function through the patient’s own biological processes. These solutions consist of natural biological compounds for use in both adult and paediatric patients.

Bonalive® granules

Bone Healing with S53P4 Bioactive Glass

Guiding Bone Regeneration from Activation to Full Restoration

At the core of this technology is S53P4 bioactive glass – a smart bioactive material that consists solely of elements that exist naturally in the human body.

Bonalive® S53P4 bioactive glass is osteoconductive and also osteoproductive in the promotion, migration, replication and differentiation of osteogenic cells and their matrix production.* Bioactive glass S53P4 consists of sodium, silicate, calcium and phosphate.

  • Activation (0-12 Days)

    When Bonalive® bioactive glass is placed into the bone cavity, it reacts with body fluids to activate the granules. During this activation period, the bioactive glass goes through a series of chemical reactions, creating ideal conditions for bone to rebuild through osteoconduction.

  • Interaction (6-12 weeks)

    Once the hydroxyapatite layer is formed, the bioactive glass interacts with biological entities, i.e. blood proteins, growth factors and collagen. Following this interactive, osteoconductive and osteostimulative** process, new bone grows onto and between the bioactive glass structures.

  • Transformation (months to years)

    In the final transformative phase, the process of bone regeneration and remodeling continues. Over time the bone fully regenerates, restoring the patient’s natural anatomy.

Bonalive granules

A Proven Solution for Bone Reconstruction and Infection Control

Bonalive® granules is a CE marked Class III medical device, providing a Smart HealingTM solution for bone infections and bone reconstruction. Bonalive® granules has been proven to naturally inhibit the bacterial growth of up to 50 clinically relevant bacteria strains.*

The clinical efficacy and performance of the granules has been proven over the past 20 years in various bone void filling applications.

By supporting the reconstruction of anatomical structures in the human body, the biodegradable S53P4 bioactive glass gets gradually resorbed and replaced by bone over a period of years. Bonalive® granules radio-dense quality enables post-operative evaluation, allowing surgeons to monitor the healing of their patients.

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Bonalive putty

A highly moldable, easy-to-apply bone regeneration technology that naturally stimulates bone formation.

Bonalive® putty is a bioactive, osteoconductive and osteostimulative* synthetic CE marked Class III medical device.

The putty is a synthetic bone graft substitute delivered as a sterile and ready-to-use paste, requiring no mixing, moistening or other preparation. The putty is available in an applicator and in a dispenser delivery system.

The putty consists of S53P4 bioactive glass in addition to a synthetic binder, i.e. a blend of polyethylene glycols (PEGs) and glycerol. The binder allows the putty to stay in place during surgery. Following its application, the binder is absorbed in a few days, leaving behind only the bioactive glass, thus permitting tissue infiltration between the bioactive glass to facilitate bone regeneration.

The putty’s radio-dense quality enables post-operative evaluation, allowing surgeons to follow the healing of their patients.

Revolutionising Patient Care

Faster Recovery, Simplified Procedures, and Cost-Effective Healthcare

  • Proven Efficacy

    The clinical efficacy and performance has been proven over the past 20 years in various bone void filling applications.

  • Post-operative Evaluation

    The radio-dense quality of Bonalive® enables post-operative evaluation, allowing surgeons to monitor the healing of their patients.

  • Cost-Effective

    Enabling procedures that are more cost-effective and more sustainable.

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